Lexikon

change in morphology, physiology, growth, development or lifespan of an organism which results in impairment of its functional capacity or impairment of its capacity to compensate for additional stress or increased susceptibility to the harmful effects of other environmental influences. (Source: REACH Glossary)

a change in body function or cell structure that might lead to disease or health problems.

highest dose with No Observable Adverse Effect. It is the highest tested dose or exposure level at which there are no statistically significant increases in the frequency or severity of adverse effects between exposed population and an appropriate control group. Some effects may be produced at this level, but they are not considered adverse ort precursors of adverse effects (Source: REACH).