Lexikon

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adsorbable organically bound halogens
see AOX
advection

to transport or carry. For example particulate matter is transported in air by wind, liquid form matter is flowing and contaminants are transported by this flow, etc.

adverse effect

change in morphology, physiology, growth, development or lifespan of an organism which results in impairment of its functional capacity or impairment of its capacity to compensate for additional stress or increased susceptibility to the harmful effects of other environmental influences. (Source: REACH Glossary)

adverse health effect

a change in body function or cell structure that might lead to disease or health problems.

aerobic

aerobic conditions or processes are those, which require oxigen. In environmental and biological systems biologically available oxigen can be derived from the atmospher in the form of atmospheric air, from the water in the form of water-dissolved oxigen for aquatic-ecosystem, or in the form of soil-air for the soil living organisms. If the oxigen is not enough or not available, the conditions are anoxic. If no oxigen is present at all, we speak about anaerobic conditions.

The biological activity in the presence of oxigen is called: aerobiosis, under anaerobic conditions: anaerobiosis.

aerodynamic noise

acoustic noise caused by turbulent airflow over the surface of a body.

aggressive cancer cells

cancer cells that are fast-growing and have a tendency to spread beyond the area where they started.

air injection
air injection into soil
air polluting substance
air polluting substances with a firm condition
air polluting substances with a natural origin
air polluting substances with an artificial origin
air pollution, technological emission limit value
air quality criteria

level of pollution, and lengths of exposure, above which adverse human health and welfare effects may occur. A prescribed level of atmospheric pollution allowed for a certain compound during a specific time in a specific geographical area. Standards are set by regulating bodies, or agencies.

air toxicology

air toxicology measures indoor and outdoor air quality and compares to quality criteria.

alcohol bioconversion
aliphatic hydrocarbons
hydrocarbons in which the carbon-hydrogen groupings are arranged in open chains (that might include branches). The term includes paraffins and olefins and provides a distinction from aromatics and naphthenes, which have at least some of their carbon atoms arranged in closed chains or rings. The paraffins, called also alkanes are saturated hydrocarbons, in their molecules the carbon atoms are bound by single bonds, e.g. hexadecane (C16H34). The olefins are unsaturated hydrocarbons, in their molecules there are carbon atoms, which are bound by double bond, e.g. hexadecene (C16H34) contains one double bond, butadiene (C4H4) contains two double bonds.
aliphyatic compound

aliphatic compounds are acyclic or cyclic, non-aromatic carbon compounds.

In aliphatic compounds, carbon atoms can be joined together in straight chains, branched chains, or non-aromatic rings (in which case they are called alicyclic). Aliphatic compounds can be saturated, joined by single bonds (alkanes), or unsaturated, with double bonds (alkenes) or triple bonds (alkynes). Besides hydrogen, other elements can be bound to the carbon chain, the most common being oxygen, nitrogen, sulfur, and chlorine.

Source: http://en.wikipedia.org/wiki/Aliphatic_compound

alkylating agents in cancer therapy

alkylating agents is a group of chemotherapy drugs. These drugs kill cancer cells by stopping their growth. They can also make it hard for cancer cells to repair damage. Some common alkylating agents are cyclophosphamide (brand name: Cytoxan) and fluorouracil (also called 5-FU or 5-fluorouracil; brand name: Adrucil).

all of dust-control degree
allocation rule, LCA
alpha-ketoglutaric acid

alpha-ketoglutaric acid bounds ammonia (in the form of α-ketoglutarate) produced by de-amination of glutamate. It plays important role in the Krebs-cycle, in the synthesis of amino-acid glutamine, in the ammonia-cycle. It is co-substrate for some oxigenase enzymes.

It is used as dietary supplement, mainly for body builders.

alternative electronacceptor
alternative energy source

any energy source that can be utilised without the use of burning fossil fuels and as a consequence without the undesired effects of the replaced fuels. Such alternative sources are almost always a renewable energy source such as hydroelectric power, wind power, solar power or bioenergy from biomass. The latter one is questionable from the point of view of eco-efficiency: a life cycle assessment may decide its ecologically friendly or not friendly character. Biogas from organic waste or briquette from waste biomass can be ecologically friendly, but palm oil produced on the soil of killed rain-forest, cannot be eco-efficient.

ambient noise or vibration source
American Society for Testing Materials ASTM

ASTM International is one of the largest voluntary standards development organizations in the world-a trusted source for technical standards for materials, products, systems, and services. Known for their high technical quality and market relevancy, ASTM International standards have an important role in the information infrastructure that guides design, manufacturing and trade in the global economy.

Source: http://www.astm.org/

amino acid

amino acids are molecules containing an amine group, a carboxylic acid group and a side chain that varies between different amino acids. Alpha-amino acids with the general formula H2NCHRCOOH, where R is an organic substituent, play important role in the metabolism of living organisms. One particularly important function is as the building blocks of proteins, which are linear chains of amino acids. Every protein is chemically defined by this primary structure, its unique sequence of amino acid residues, which in turn define the three-dimensional structure of the protein.

Amino acids are synthesized from Glutamate, which is formed by amination of α-ketoglutarate:

α-Ketoglutarate + NH4+ = Glutamate

Afterwards, Alanine and Aspartate are formed by transamination of Glutamate. All of the remaining amino acids are then constructed from Glutamate or Aspartate, by transamination of these two amino acids with one α-keto acid.

Humans are able to synthetise only part of the necessary amino-acids, 8 pf them are so calle essential aminoacids, which should be taken up by nutrition. The essential amino acids are: Isoleucine, Leucine, Lizyne, Methionine, Phenylalanine, Threonine, Tryptophane and Valine.

anaerobic

anaerobic is a technical word which means without air. Air is generally used to mean atmospheric oxygen. Anaerobic is the opposite aerobic.

In the environmnetal technologies the absence of atmospheric oxygen is indicated as anoxic; and anaerobic is used to indicate the absence of a common electron acceptor such as nitrate, sulfate or oxygen.

anaerobic biodegradation, anaerobic digestion
anaerobic digestion based technology
analyte, a substance to be analysed

a substance measured in the laboratory. A chemical substance for which a sample (such as water, air, or blood) is tested in a laboratory. For example, if the analyte is cadmium, the laboratory test will determine the amount of cadmium in the sample and the result will be given in Cd-concentration.

anionic detergents
Annex I of Directive 67/548/EEC

Annex I of Directive 67/548/EEC contains a list of harmonised classifications and labellings for substances or groups of substances, which are legally binding within the EU.
The list is regularly updated through Adaptations to Technical Progress (ATP). Revised and new classifications inserted to the list are proposed by DG ENV (EC Directorate General responsible for environment) and agreed by a Member State vote.
The DG ENV proposal is based on advice from the Technical Committee for Classification and Labelling (TC C&L) with participation of experts from the Member States.
The list is published in OJ L 152 of 30/04/2004 and can be found on the following web-address: http://www.reach-compliance.eu/english/legislation/docs/launchers/launch-annex-1-67-548-EEC.html

Annex VI, CLP

Annex VI of the CLP Regulation contains the list of substances, which should be classified according to harmonised classification (legal classification: GHS, Globally Harmonized System). The same role filled formerly Annex I of Directive 67/548/EEC.

Annex XIII, REACH

Annex XIII contains criteria for the identification of persistent, bioaccumulative and toxic (PBT) substances, and very persistent and very bioaccumulative substances (vPvB).

Source: REACH

Annex XIV, REACH

Annex XIV: Authorisation Priority List, contains the substances which are subject of authorisation and the specific timeline for sunsetting & application.

Source: REACH

Annex XV. dossier, REACH

Annex XV dossiers are the regulatory instruments for the Authorities (Member States or the Agency) to propose and justify:

  • a harmonised classification and labelling of substances as carcinogenic, mutagenic and or toxic to reproduction (CMR) and as respiratory sensitisers, or for any other endpoint if justification for action at Community level can be provided. Agreement on a dossier for harmonised classification and labelling will lead to the addition of the classification to Annex I of Directive 67/548/EEC.
  • the identification of CMR substances, PBT substances, vPvB substances or substances of an equivalent level of concern. Agreement on the identification of a substance as a PBT, vPvB or of an equivalent level of concern means that it is a substance of very high concern and is to be included in the candidate list of substances for eventual inclusion in Annex XIV of the REACH Regulation, and through this be subject to authorisation. Substances with PBT or vPvB properties, wide dispersive use or high volumes will be priority substances for inclusion in Annex XIV.
  • Restriction on the manufacture, placing on the market or use of substances within the Community. Agreement on proposed restrictions will lead to the addition of any agreed restrictions to Annex XVII of the REACH Regulation. Any subsequent manufacture, placing on the market or use of the substance has to comply with the conditions of the restrictions.

Annex XV of the REACH Regulation lays down general principles for preparing these three types of dossier.

Source: REACH

Annex XVI, REACH

Annex XVI is the socio-economic analysis of the substance in question.

Annex XVII, REACH

Annex XVII contains restrictions on the manufacture, placing on the market and use of certain dangerous substances, preparations and articles.

Source: REACH

anoxic
anthracene
antibiotic resistance

antibiotic resistance is the ability of a microorganism to withstand the effects of antibiotics. Antibiotic resistance evolves via natural selection acting upon random mutation, but it can also be engineered by applying an evolutionary stress on a population. Once such a gene is generated, bacteria can then transfer the genetic information in a horizontal fashion (between individuals) by plasmid exchange.

If a bacterium carries several resistance genes, it is called multiresistant.

Antibiotic resistance can also be introduced artificially into a microorganism through transformation protocols. This can aid in implanting artificial genes into the microorganism. If the resistance gene is linked with the gene to be implanted, the antibiotic can be used to kill off organisms that lack the new gene.

antibiotics

an antibiotic (from the Ancient Greek: anti = "against", and bios = "life") is a substance or compound that kills or inhibits the growth of bacteria or other microorganisms. It is based on a natural phenomenon, antibiosis, which means antagonistic association between an organism and the metabolic substances produced by another. Formerly only the microbes-made substances were called "antibiotics", but today all man-made, synthetic or semisynthetic compounds are called "antibiotic", which are prodused and used for the inhibition or killing microbes. We distinguish between antibacterial, antifungal, antiprozoal etc. Antibiotics, depending on the target of the antibiotic agent. Antibiotics belong to the broader group of antimicrobial compounds, used to treat infections in humans and animals caused by microorganisms, to treat food or fodder to prevent fauling and infections through nutrition, etc.

microorganisms easily get resistant to antibiotics, due to a special mechanism, where the gene responsible for the antibiotic resistence moves from one organism to the other in form of mobile genetic elements, causing rapid transformation of a sensitive bacterial populations (e.g. in human body) into a resistent one.

See also antibiotic resistance

antineoplastic agents

chemotherapy is the treatment of cancer with an antineoplastic drug or with a combination of such drugs into a standardized treatment regimen.

The most common chemotherapy agents act by killing cells that divide rapidly, one of the main properties of most cancer cells. This means that chemotherapy also harms cells that divide rapidly under normal circumstances: cells in the bone marrow, digestive tract, and hair follicles. This results in the most common side-effects of chemotherapy: myelosuppression (decreased production of blood cells, hence also immunosuppression), mucositis (inflammation of the lining of the digestive tract), and alopecia (hair loss).

Newer anticancer drugs act directly against abnormal proteins in cancer cells; this is termed targeted therapy and, in the technical sense, is not chemotherapy.

The types of antineoplastic agents are the following:

1 Alkylating agents

1.1 Nitrogen mustard analogues

1.2 Alkyl sulfonates

1.3 Ethylene imines

1.4 Nitrosoureas

1.5 Epoxides

1.6 Other alkylating agents

2 Antimetabolites

2.1 Folic acid analogues

2.2 Purine analogues

2.3 Pyrimidine analogues

3 Plant alkaloids and other natural products

3.1 Vinca alkaloids and analogues

3.2 Podophyllotoxin derivatives

3.3 Colchicine derivatives

3.4 Taxanes

3.5 Other plant alkaloids and natural products

4 Cytotoxic antibiotics and related substances

4.1 Actinomycines

4.2 Anthracyclines and related substances

4.3 Other cytotoxic antibiotics

5 Other antineoplastic agents

5.1 Platinum compounds

5.2 Methylhydrazines

5.3 Monoclonal antibodies

5.4 Sensitizers used in photodynamic/radiation therapy

5.5 Protein kinase inhibitors

5.6 Other antineoplastic agents

5.7 L01XY Combinations of antineoplastic agents

Source: http://en.wikipedia.org/wiki/ATC_code_L01

antropogenic
application of microbial inoculant for soil remediation
application of microbial inoculatnts
applied research and development
approved dosimetric service

approved dosimetric service: a body responsible for the calibration, reading or interpretation of individual monitoring devices, or for the measurement of radioactivity in the human body or in biological samples, or for assessment of doses, whose capacity to act in this respect is recognized by the competent authorities.

Source: Council Directive 96/29 EURATOM, http://ec.europa.eu/energy/nuclear/radioprotection/doc/legislation/9629_en.pdf