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benchmark dose (BMD

the BMD concept involves fitting a mathematical model to dose-response data. The BMD is defined as the dose causing a predetermined change in response.

Source: REACH

Benchmark Dose (BMD), REACH

the BMD concept involves fitting a mathematical model to dose-response data. The BMD is defined as the dose causing a predetermined change in response.
The BMD10 Benchmark-dose associated with a 10% response (for tumours upon lifetime exposure after correction for spontaneous incidence, for other effects in a specified study.
The BMDL10 is the lower 95% confidence interval of a Benchmark-dose representing a 10% response (e.g., tumour response upon lifetime exposure), i.e. the lower 95% confidence interval of a BMD10. (Source: REACH Glossary)